OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness
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منابع مشابه
The Oct4 protein: more than a magic stemness marker.
The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25 years ago, to be absolutely required for the stemness properties of murine and primate embryonic stem cells. This transcription factor, which has also been shown to be essential for somatic cell reprogrammation, displays various functions depending upon its level of expression and has been quoted as a "rh...
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BACKGROUND The human OCT4 gene, responsible for pluripotency and self-renewal of Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells, can generate several transcripts (OCT4A, OCT4B-variant 2, OCT4B-variant 3, OCT4B-variant 5, OCT4B1, OCT4 B2 and OCT4B3) by alternative splicing and alternative promoters. OCT4A that is responsible for ES and EC cell stemness properties is transcribed from a pr...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2009
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gap018